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September 10, 2025Open Access

Figure S11 from Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis

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Different immune response dynamics in lymph nodes and primary tumors can affect metastatic susceptibility.
Treg and CD8 IL-2 interactions show significant divergence between tumor-draining lymph nodes and primary sites.
Understanding these dynamics may provide new insights into how metastasis spreads in cancer.
The findings highlight an important area of research in cancer immunology, focusing on lymph node behavior.

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Observational analysis shows differing Treg-CD8 IL-2 dynamics in lymph nodes and primary tumors, indicating susceptibilities to metastasis.

Treg-CD8 IL-2 response dynamics diverge between tdLNs and primary tumor

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Kahn et al. (2025) studied this question.

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Observational analysis shows differing Treg-CD8 IL-2 dynamics in lymph nodes and primary tumors, indicating susceptibilities to metastasis.

Treg-CD8 IL-2 response dynamics diverge between tdLNs and primary tumor