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September 10, 2025Open Access

Figure S12 from Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis

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Tregs proximity to CD8 T cells may influence the immune response and metastasis susceptibility.
In tdLNs, Tregs are notably closer to CD8 T cells compared to their arrangement in primary tumors.
This analysis highlights the potential immunological vulnerabilities of lymph nodes in metastatic progression.
Further insights could inform therapeutic strategies targeting immune response in tumor environments.

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Observational analysis shows Tregs are closer to CD8 T cells in lymph nodes than in primary tumors, suggesting a link to metastasis.

Tregs are closer to CD8 T cells in tdLNs than in primary tumors

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Kahn et al. (2025) studied this question.

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Observational analysis shows Tregs are closer to CD8 T cells in lymph nodes than in primary tumors, suggesting a link to metastasis.

Tregs are closer to CD8 T cells in tdLNs than in primary tumors