Vitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of the Lessening Organ Dysfunction With Vitamin C Randomized Trial

This is a Post hoc analysis study (also classified as: Randomized trial).

September 1, 2025Critical Care ExplorationsOpen Access

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Key Points

Vitamin C administration does not increase mortality risk associated with platelet counts in septic patients.
The hazard ratio was 0.97 per 10 × 10 9 /L increase in platelet count, highlighting no significant impact from vitamin C.
This post hoc analysis is derived from the LOVIT randomized trial, focusing on patients with confirmed or suspected infections.
Findings indicate that vitamin C's role in platelet behavior during sepsis may not be clinically significant.

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Post hoc analysis shows no impact of vitamin C on platelet counts or mortality in sepsis patients, suggesting alternative factors may be at play.

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Müller et al. (2025) studied this question.

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