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September 1, 2025Open Access

Vitamin C Does Not Affect Platelet Counts in Patients With Sepsis: A Post hoc Analysis of the Lessening Organ Dysfunction With Vitamin C Randomized Trial

Mattia Müller Ruxandra Pinto François Lamontagne Neill KJ Adhikari Lorenzo Del Sorbo for the Lessening Organ Dysfunction With Vitamin C (LOVIT) Investigators

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Key Points

The aim is to explore if vitamin C affects mortality in septic patients through changes in platelet counts.
Post hoc analysis of the LOVIT randomized trial
Included patients with an ICU stay longer than 24 hours
Administered vitamin C or placebo every 6 hours for 4 days
Collected and analyzed platelet count and mortality data
No significant interaction between vitamin C and mortality related to platelet count
Longitudinally, platelet count trajectory was associated with mortality
No evidence supporting vitamin C increasing mortality risk via platelet count changes

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Implication

Post hoc analysis shows vitamin C does not influence mortality or platelet counts in septic patients, suggesting limited effects.

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Cite This Study

Müller et al. (2025) studied this question.

synapsesocial.com/papers/699a9dc0482488d673cd3e22 https://doi.org/10.5167/uzh-291972

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