Biologic Agents in Noninfectious Uveitis: A Comprehensive Review

Uveitis is a multifaceted condition characterized by inflammation affecting the anterior, intermediate, and posterior segments of the uveal tract, with etiologies ranging from inflammatory, infectious, to neoplastic origins. While various strategies exist to suppress the inflammatory response, the conventional approach of corticosteroid monotherapy, both locally and systemically, is increasingly deemed inadequate due to its significant side effects, prompting concerns. In recent years, biologic agents have emerged as promising alternatives for uveitis management. However, their widespread adoption is hindered by the considerable expense associated with these therapies, particularly impeding access in resource-limited settings. This review aims to provide a comprehensive analysis of available biologic treatment options for noninfectious uveitis, incorporating insights from clinical studies and recent advancements in pharmacology.