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September 10, 2025Frontiers in PharmacologyOpen Access

Preventive effect of sodium bicarbonate Ringer’s solution on post-contrast acute kidney injury in patients undergoing percutaneous coronary intervention

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Randomized trial reduced post-contrast acute kidney injury in patients with chronic kidney disease, suggesting sodium bicarbonate may be effective.

Post-contrast acute kidney injury occurred in 1.3% of patients receiving sodium bicarbonate Ringer’s solution versus 9.3% in the normal saline group, indicating a significant protective effect.
Statistical analysis showed P=0.029 for lower incidence of acute kidney injury in the BRS group compared to the NS group.
Patients were randomly assigned to receive either sodium bicarbonate Ringer’s solution or normal saline for hydration before and after coronary angiography.
The findings highlight the potential benefits of sodium bicarbonate Ringer’s solution in preventing acute kidney injury during coronary procedures.

Liu et al. (2025) studied this question.

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Randomized trial reduced post-contrast acute kidney injury in patients with chronic kidney disease, suggesting sodium bicarbonate may be effective.