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September 10, 2025GSC Biological and Pharmaceutical Sciences

Anti-inflammatory Activity of Acutely Administered Methanolic Leaf Extract of Croton zambesicus Linn in Laboratory Rats

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Authors

BPBitrus Danladi PofiOMOlusayo MoritiwonUniversity of JosTOTimothy Olugbenga OgundekoBingham University

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Implication

Investigation shows significant reduction in paw oedema in rats, suggesting Croton zambesicus has potent anti-inflammatory potential.

Key Points

  • The methanolic leaf extract of Croton zambesicus led to significant reduction in paw oedema.
  • The highest dose tested, 100 mg/kg, produced effects comparable to the standard drug diclofenac.
  • Phytochemical analysis revealed the presence of alkaloids and saponins, indicating its medicinal properties.
  • The LD₅₀ value of 3807.98 mg/kg suggests a high safety margin for the extract.

Cite This Study

Pofi et al. (2025) studied this question.

synapsesocial.com/papers/68c193f19b7b07f3a06180d0https://doi.org/10.30574/gscbps.2025.32.3.0334
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ziziphus abyssinica hydro-ethanolic root bark extract attenuates acute inflammation possibly through membrane stabilization and inhibition of protein denaturation and neutrophil degranulation2026
  2. 2In vivo Investigation of the Therapeutic Potential of Ziziphus mauritiana Against Inflammatory Bowel Disease in Albino Wistar Rats2024
  3. 3Evaluation of acute and subacute anti-inflammatory activity of Crocus sativus ethanolic extract water fraction in rats2026
  4. 4Anti-Inflammatory Activity Test of Dendrophthoe glabrescens (Blakely) Barlow Leaf Extract on Mice (Mus musculus) Induced with Carrageenan2025
  5. 5Anti-inflammatory and anti-arthritic activities of ethanolic extract of Myxopyrum serratulum A.W. Hill2024 · 4 citations