The interplay between hormonal, metabolic status and cognitive functions in long-living individuals

Background. Cognitive impairment (CI) is one of the most common geriatric syndromes, which has a significant negative impact on the autonomy and quality of life of older patients. It seems promising to study the association of the neuropsychological status of individuals over 90 years old with the parameters of their clinical and geriatric status in order to identify potential modifiable risk factors for the occurrence and progression of CI in this age group. Aim. To assess the relationship between hormonal and metabolic parameters and the neuropsychological status of long-livers. Materials and methods. The study included 3494 people aged 90 years and older. During a medical team visit, the study participants underwent a comprehensive geriatric assessment, as well as blood sampling to determine a number of metabolic and hormonal parameters. Cognitive functions were assessed using the Mini Mental State Examination, as well as the Frontal Assessment Battery. Depression symptoms were assessed using the Geriatric Depression Scale. Statistical analysis of the data was performed using the R programming languages version 4.2.2. and Python version 3.9.12. Results. Despite the correlation between the test results on the scales described above, different types of dementia have their own hormonal and metabolic markers. Thus, it is neurodegenerative conditions diagnosed with Mini Mental State Examination, that are associated with HDL-cholesterol and apolipoprotein A1. Whereas frontal dysfunction diagnosed with Frontal Assessment Battery is more associated with adiponectin. For depression, no unique markers not associated with the progression of CI were found. Conclusion. Different hormonal and metabolic parameters make a significant contribution to determining the severity of cognitive impairment in long-livers, depending on the specific type of neurological disorders. The obtained data require confirmation in prospective studies and may further be promising for optimizing guidelines for diagnosis, treatment and prevention of CI in long-livers.