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September 10, 2025Veterinary WorldOpen Access

A novel influenza vector-based vaccine expressing ESAT-6 and TB10.4 confers immunity and protection against Bovine tuberculosis in guinea pigs and calves

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Authors

ANAinur NurpeisovaKazakh Scientific Research Veterinary InstituteZAZhandos AbayKazakh Scientific Research Veterinary InstituteMKMarkhabat KassenovKazakh Scientific Research Veterinary Institute

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Implication

This study evaluates a novel vaccine's immunogenicity and safety in guinea pigs and calves, highlighting its potential against Mycobacterium bovis.

Key Points

  • The novel influenza vector-based vaccine demonstrates significant protection against Mycobacterium bovis infection.
  • In guinea pigs, the non-adjuvanted vaccine showed a protection index reaching +0.60 lg, indicating strong efficacy.
  • Safety assessments revealed no adverse reactions in guinea pigs and calves during the 12-month evaluation period.
  • The adjuvant-free formulation outperformed traditional BCG vaccines, suggesting a new alternative for bovine tuberculosis control.

Cite This Study

Nurpeisova et al. (2025) studied this question.

synapsesocial.com/papers/68c1954e9b7b07f3a0618a3ahttps://doi.org/10.14202/vetworld.2025.2573-2589
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