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September 8, 2025Open Access

Figure 2 from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis

Kohinoor Khan Mohammad Shameem Ashley N. Sigafoos Linda Kiey Catherine E. Hagen Gopal Ramakrishnan Leslie R. Morse Martín E. Fernández-Zapico Ricardo A. Battaglino

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Key Points

SNX10 overexpression decreases cell proliferation in PDAC cell lines, enhancing G1 phase presence.
Cell cycle analysis shows a significant increase in G1 phase cells in the SNX10 overexpressing group compared to control.
Western blotting confirmed SNX10 expression in both AsPC1 and HPAF-II cell lines during experimentation.
Data indicate that alterations in SNX10 levels influence pancreatic tumorigenesis and cell cycle dynamics.

Implication

Loss of SNX10 enhances pancreatic tumorigenesis via altered cell proliferation and growth rate metrics.

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Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/68c198be9b7b07f3a061a640 https://doi.org/10.1158/2767-9764.30073745

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure 3 from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis2025
2Figure 1 from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis2025
3Figure 5 from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis2025
4Data from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis2025
5Loss of Sorting Nexin 10 accelerates KRAS-induced pancreatic tumorigenesis.2025 · 1 citations