Figure 3 from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis

Kohinoor Khan; Mohammad Shameem; Ashley N. Sigafoos; Linda Kiey; Catherine E. Hagen; Gopal Ramakrishnan; Leslie R. Morse; Martín E. Fernández-Zapico; Ricardo A. Battaglino

doi:10.1158/2767-9764.30073742

September 8, 2025Open Access

Figure 3 from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis

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Key Points

Overexpression of SNX10 significantly affects levels of protumorigenic markers in pancreatic cancer cells, highlighting its role in tumorigenesis.
Western blot analysis revealed significant differences in SRC, STAT3, and ERK expression, indicating the impact of SNX10 on various signaling pathways.
AsPC1 and HPAF-II cell lines were used, highlighting that the findings are representative across different pancreatic cancer models.
Data derived from three independent experiments show convincing results, supporting the conclusion that SNX10 is a key player in KRAS-induced cancer progression.

Implication

Observational analysis found that SNX10 overexpression alters protumorigenic marker levels in cell lines, suggesting its involvement in KRAS-driven tumorigenesis.

Discussion

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Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/68c198c59b7b07f3a061a6ee https://doi.org/10.1158/2767-9764.30073742

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Figure 3 from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis

Key Points

Implication

Discussion

Cite This Study

Figure 3 from Loss of Sorting Nexin 10 Accelerates KRAS-Induced Pancreatic Tumorigenesis

Key Points

Implication

Discussion

Cite This Study

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