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September 10, 2025Regional Anesthesia & Pain Medicine

Enhancement of Analgesic Effect of Intrathecal Neostigmine and Clonidine on Bupivacaine Spinal Anesthesia

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Authors

PPPeter PanCHC. T. HuangTWT T Wei

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Overview

Randomized trial shows improved analgesia with intrathecal neostigmine and clonidine, suggesting significant clinical benefits.

Key Points

  • The combination of intrathecal clonidine and neostigmine provided significantly longer postsurgical analgesia.
  • The bupivacaine + both group experienced a maximum spread of anesthesia of 23.3 segments compared to 20.5 segments in the bupivacaine group.
  • Motor block duration was prolonged from 3.5 hours in the bupivacaine group to 7.1 hours when both drugs were combined.
  • Increased side effects, including nausea and dizziness, were noted in the group receiving both medications.

Cite This Study

Pan et al. (1998) studied this question.

synapsesocial.com/papers/68c19ab49b7b07f3a061c93chttps://doi.org/10.1136/rapm-00115550-199823010-00010
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