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September 10, 2025IAR Journal of Anaesthesiology and Critical Care

Intrathecal Bupivacaine with Neostigmine 25mcg Vs 50mcg, Which One Is a Better Choice for Infra–Umbilical Abdominal Surgeries? A Prospective Randomized Comparative Study

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Authors

RReshamBRB Narasimha ReddyAGApoorva Gupta

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Overview

Prospective study compares 25mcg and 50mcg neostigmine added to bupivacaine, highlighting efficacy and side effects.

Key Points

  • Motor and sensory block duration was significantly prolonged when neostigmine was added to bupivacaine for spinal anesthesia.
  • Patients receiving 50mcg neostigmine reported the highest incidence of nausea and vomiting post-surgery.
  • Elective abdominal surgeries under spinal anesthesia allowed for a clear comparison of neostigmine doses and their effects.
  • The addition of 25mcg of neostigmine was recommended for optimal balance between effectiveness and side effects.

Cite This Study

Resham et al. (2023) studied this question.

synapsesocial.com/papers/68c1e24d54b1d3bfb60ff549https://doi.org/10.47310/iarjacc.2023.v04i01.011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1COMPARATIVE STUDY OF INTRATHECAL BUPIVACAINE WITH OR WITHOUT NEOSTIGMINE FOR INFRAUMBILICAL SURGERIES2017
  2. 2COMPARISON BETWEEN INTRATHECAL NEOSTIGMINE AND FENTANYL AS ADJUVANT TO HYPERBARIC BUPIVACAINE IN SPINAL ANAESTHESIA FOR POST-OPERATIVE PAIN RELIEF2024
  3. 3A comparative study on the effect of intrathecal nalbuphine and buprenorphine as an adjuvant to 0.5% hyperbaric bupivacaine in elective infraumbilical surgeries2024 · 3 citations
  4. 4Enhancement of Analgesic Effect of Intrathecal Neostigmine and Clonidine on Bupivacaine Spinal Anesthesia1998 · 1 citations
  5. 5Comparative Evaluation of Intrathecal Nalbuphine as an Adjuvant to Bupivacaine in Elective Cesarean Sections: A Randomized, Double-blind, Controlled Trial2025