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September 10, 2025Scientific ReportsOpen Access

Green PEGylated-Sily@ZnFe2O4 nanocomposites for amelioration of ROS and DNA damage in rat liver

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Authors

MWMuhammad WaqasMSMuhammad Saqib SaifSBSana Batool

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Overview

Observational analysis reveals PEGylated-Sily@ZnFe2O4 reduces DNA damage in rat liver, suggesting its potential as an antioxidant treatment.

Key Points

  • PEGylated-Sily@ZnFe2O4 nanocomposites significantly reduced DNA damage in CCl4-intoxicated rat liver.
  • Analysis showed that the nanocomposite had an average loading efficiency of 27.39% for silymarin.
  • In vivo experiments demonstrated the hepatoprotective effect of PEGylated-Sily@ZnFe2O4 against oxidative stress.
  • Zinc ferrite nanocomposites effectively ameliorated oxidative stress parameters in liver tissue.

Cite This Study

Waqas et al. (2025) studied this question.

synapsesocial.com/papers/68c19f9154b1d3bfb60dadf5https://doi.org/10.1038/s41598-025-14126-5
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