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September 10, 2025CureusOpen Access

Neuroleptic Malignant Syndrome in an Institutionalized Geriatric Patient Following Antipsychotic Switch to Quetiapine: A Fatal Outcome

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Authors

IEIdalberto Luis Fernandez EngACArménio CruzEEEugenia Espinosa

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Overview

Case report details a fatal episode of neuroleptic malignant syndrome in an elderly male, suggesting urgent recognition and management.

Key Points

  • Neuroleptic malignant syndrome emerged four days after quetiapine initiation in a 76-year-old patient.
  • Clinical signs included severe hyperthermia and muscle rigidity, along with altered mental status.
  • Despite early intervention, including dantrolene, the patient's condition worsened, leading to death.
  • Polypharmacy in elderly patients raises complexity, highlighting the need for vigilant monitoring.

Cite This Study

Eng et al. (2025) studied this question.

synapsesocial.com/papers/68c19f9c54b1d3bfb60db19fhttps://doi.org/10.7759/cureus.89077
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