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January 10, 2021CureusOpen Access

Atypical Neuroleptic Malignant Syndrome in the Setting of Quetiapine Overdose: A Case Report and Review of the Literature

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Why the study?

The literature lacks an objective measure for diagnosing neuroleptic malignant syndrome, and concomitant toxicities or atypical presentations can distort the clinical picture.

Population

A 44-year-old Caucasian man with atypical NMS after quetiapine overdose

Design

Case report and review of the literature

Authors

SHSheila D HernandezDMDario MarottaRGRavitej Goteti

Discussion

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Member takes

Overview

Afebrile NMS after SGA overdose warrants vigilance; this case leaves open revised diagnostic criteria.

Structured PICO

P
Population
44-year-old Caucasian male with a history of attention-deficit hyperactivity disorder and major depressive disorder with psychotic symptoms, presenting with atypical neuroleptic malignant syndrome (NMS) after quetiapine overdose (n=1).
I
Intervention
Quetiapine overdose (found with empty bottle of quetiapine, prescribed 30 mg daily) managed with supportive care and hemodialysis.

Atypical neuroleptic malignant syndrome can present without fever in the setting of second-generation antipsychotic overdose, requiring prompt recognition and management.

Cite This Study

Hernandez et al. (2021) studied this question.

synapsesocial.com/papers/6a81ea612f94e177df06dbe3https://doi.org/10.7759/cureus.12602
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