March 20, 2009Psychiatry and Clinical NeurosciencesOpen Access

Neuroleptic malignant syndrome with use of quetiapine in mental retardation

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Population

1 20-year-old man with severe mental retardation and a 2-year history of frequent unprovoked aggression.

Design

Case_report

Authors

ADAmitava Dan RBRahul S. Bharadwaj SGSandeep Grover

Discussion

Member takes

Overview

Alerts clinicians to possible fatal NMS with quetiapine-haloperidol addition; leaves open systematic safety evaluation in vulnerable patients.

Structured PICO

Population

1 20-year-old man with severe mental retardation (IQ = 27) and a 2-year history of frequent unprovoked aggression.

Intervention

Quetiapine (initially 100 mg/day, increased to 200 mg/day) added to haloperidol.

Outcome

Development of neuroleptic malignant syndrome (NMS)safety

This case report highlights the risk of developing fatal neuroleptic malignant syndrome when quetiapine is added to another antipsychotic like haloperidol, especially in patients with vulnerability factors.

Cite This Study

Dan et al. (2009) studied this question.

synapsesocial.com/papers/6a726e9978a11c550e0c30b5 https://doi.org/10.1111/j.1440-1819.2008.01921.x

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March 20, 2009Psychiatry and Clinical NeurosciencesOpen Access

Neuroleptic malignant syndrome with use of quetiapine in mental retardation

View Full Paper

Ask AI

Bookmark

Population

1 20-year-old man with severe mental retardation and a 2-year history of frequent unprovoked aggression.

Design

Case_report

Authors

ADAmitava Dan RBRahul S. Bharadwaj SGSandeep Grover

Discussion

Member takes

Overview

Alerts clinicians to possible fatal NMS with quetiapine-haloperidol addition; leaves open systematic safety evaluation in vulnerable patients.

Structured PICO

Population

1 20-year-old man with severe mental retardation (IQ = 27) and a 2-year history of frequent unprovoked aggression.

Intervention

Quetiapine (initially 100 mg/day, increased to 200 mg/day) added to haloperidol.

Outcome

Development of neuroleptic malignant syndrome (NMS)safety

Cite This Study

Dan et al. (2009) studied this question.

synapsesocial.com/papers/6a726e9978a11c550e0c30b5 https://doi.org/10.1111/j.1440-1819.2008.01921.x

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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