Key result
Single 300 mg quetiapine dose linked to reversible neuroleptic malignant syndrome.
Why the study?
Neuroleptic malignant syndrome is a life-threatening neurological emergency requiring prompt recognition to reduce significant morbidity and mortality.
Case Report (n=1)
Prompt recognition and management of neuroleptic malignant syndrome following quetiapine administration is crucial to reduce morbidity and mortality.
Neuroleptic malignant syndrome (NMS) is a life-threatening neurological emergency that has been observed to occur in some patients following the administration of anti-dopaminergic agents or the rapid withdrawal of dopaminergic medications. In this report, the authors present a case of a 51-year-old male patient with a known history of cocaine abuse, who was given quetiapine during his hospitalization. This precipitated an episode of NMS that eventually concluded uneventfully due to quick diagnosis and management. Prompt recognition of the condition is required to reduce significant morbidity and mortality. Ultimately, maintaining vigilance for the clinical features of NMS is crucial for timely diagnosis and intervention.
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Paul et al. (2022) conducted a case report in Neuroleptic Malignant Syndrome (n=1). Quetiapine was evaluated on Development of Neuroleptic Malignant Syndrome (NMS). A 51-year-old male developed neuroleptic malignant syndrome following a single 300 mg dose of the atypical antipsychotic quetiapine, which resolved after discontinuation and supportive care.
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