This research outlines efficient N-acylation of sulfoximines using Pd-NHC catalyst, showing promising yields with aryl esters.
Aryl esters have emerged as commonly used reagents for acylation reactions in chemical synthesis, and can be utilized for N-acylation of sulfoximines in the present work. The reactions proceed efficiently with an air- and moisture-stable Pd-NHC (N-heterocyclic carbene) precatalyst, in which various NH-sulfoximines and functionalized aryl esters are well tolerated, enabling the formation of N-aroylsulfoximine products in good to excellent yields.
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Zhong et al. (2025) studied this question.
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