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September 10, 2025Journal of Thoracic DiseaseOpen Access

Pregnancy in patients with pulmonary hypertension: a systematic review and meta-analysis with meta-regression

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Authors

MIMahmoud El IskandaraniRGReshma GolamariBBBranco Gonzalo Matias Bettinotti

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Overview

Systematic review and meta-analysis identifies high maternal mortality and risks in patients with pulmonary hypertension, indicating severe cases require careful management.

Key Points

  • Maternal mortality rate in pregnant patients with pulmonary hypertension was 7.6%, highlighting significant risk.
  • Severe pulmonary hypertension was linked to a 5.57 times higher risk of maternal death compared to mild cases.
  • Event rates for abortion, prematurity, and small gestational age were significantly higher in severe pulmonary hypertension patients.
  • The findings emphasize the need for personalized risk assessments for pregnancy in severe pulmonary hypertension cases.

Cite This Study

Iskandarani et al. (2025) studied this question.

synapsesocial.com/papers/68c1a12754b1d3bfb60dbee3https://doi.org/10.21037/jtd-2025-430
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Evaluation of maternal-fetal outcomes in pregnancy complicated with severe pulmonary hypertension and its influencing factors: a single-center retrospective study in China2023 · 8 citations
  2. 2Clinical outcomes of pregnancy in patients with pulmonary hypertension: A single center observational study2025 · 10 citations
  3. 3Pregnancy and pulmonary hypertension2018 · 30 citations
  4. 4Pulmonary Hypertension Complicating Pregnancy2021 · 17 citations
  5. 5Pregnancy outcomes in women with pulmonary hypertension: a retrospective study in China2022