Key result
Severe pulmonary hypertension is linked to a ~28% maternal mortality rate versus milder forms.
Why the study?
Although pregnancy is contraindicated in pulmonary hypertension, favorable outcomes have been observed when disease is well controlled, leaving unanswered questions regarding outcomes and risk predictors.
Population
118 pregnant women with pulmonary hypertension
Comparison
Groups categorized by SPAP: 40-50 mmHg (group A) vs 50-70 mmHg (group B) vs >= 70 mmHg (group C)
Design
Single-center retrospective observational study
Authors
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Highlights persistent maternal risks in pulmonary hypertension pregnancies; challenges guideline contraindications yet remains hypothesis-generating.
Observational (n=118)
No
Absolute Event Rate: 27.8% vs 1%
p-value: p=< 0.001
Pregnancy in women with severe pulmonary hypertension and elevated NT-proBNP carries a high risk of maternal mortality, whereas those with mild to moderate PH may have favorable outcomes with multidisciplinary management.
Pan et al. (2025) conducted an observational in Pulmonary hypertension in pregnancy (n=118). Severe pulmonary hypertension (SPAP ≥ 70 mmHg) vs. Mild to moderate pulmonary hypertension (SPAP 40-70 mmHg) was evaluated on Maternal mortality (p=< 0.001). Severe pulmonary hypertension (SPAP ≥ 70 mmHg) was associated with a significantly higher maternal mortality rate of 27.8% compared to 0% in mild and 4.6% in moderate pulmonary hypertension.
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