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December 6, 2023The Journal of Maternal-Fetal & Neonatal MedicineOpen Access

Pregnancy in women with severe pulmonary hypertension carried a 28% maternal mortality rate, with NYHA cardiac function grade III-IV being useful in predicting the risk of mortality.

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Why the study?

Pregnancy poses significant maternal and fetal risks in patients with severe PH, motivating an evaluation of maternal-fetal outcomes and their influencing factors.

Population

25 patients with severe PH admitted to a single hospital

Design

Single-center retrospective study

Key result

Pregnancy in women with severe pulmonary hypertension carried a 28% maternal mortality rate, with NYHA cardiac function grade III-IV being useful in predicting the risk of mortality.

Authors

QDQiulan DaiFujian Medical UniversityMSManman ShangFujian Medical UniversityYZYu ZhouSecond Military Medical University

Discussion

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Member takes

Overview

Severe PH pregnancy outcomes remain high-risk; retrospective data leaves open need for prospective risk-stratification studies.

Study Design

Type

Observational (n=25)

Multicenter

No

Structured PICO

P
Population
25 pregnant women with severe pulmonary hypertension admitted to a single center in China between 2018 and 2022.
E
Exposure
Multidisciplinary team (MDT) treatment and pregnancy management/termination
O
Outcome
Maternal-fetal outcomes including maternal mortality, complications (pulmonary hypertensive crisis, heart failure, postpartum hemorrhage), and fetal outcomes (therapeutic abortion, preterm birth, neonatal asphyxia, low birth weight, perinatal death)hard clinical

Pregnancy in women with severe pulmonary hypertension carries a 28% mortality risk, strongly supporting recommendations for contraception in this population.

Cite This Study

Dai et al. (2023) conducted an observational in Severe pulmonary hypertension in pregnancy (n=25). Severe pulmonary hypertension was evaluated on Maternal mortality. Pregnancy in women with severe pulmonary hypertension carried a 28% maternal mortality rate, with NYHA cardiac function grade III-IV being useful in predicting the risk of mortality.

synapsesocial.com/papers/6a616ee32004386bc7d0a371https://doi.org/10.1080/14767058.2023.2290923
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Maternal and fetal/neonatal outcomes of pregnancies complicated by pulmonary hypertension: a retrospective study of 154 patients2023 · 8 citations
  2. 2Pregnancy outcomes in women with pulmonary hypertension: a retrospective study in China2022
  3. 3Pregnancy outcomes in women with pulmonary hypertension: a retrospective study in China2023 · 20 citations
  4. 4Maternal and neonatal outcomes in pregnancies complicated with pulmonary hypertension: a retrospective cohort study2025 · 6 citations
  5. 5Maternal and Neonatal Outcomes in Pregnancy Complicated with Pulmonary Hypertension2022 · 4 citations