Maternal and Infant Outcomes of Pregnancy Complicated by Pulmonary Hypertension: A Single-Center Retrospective Study from China

Background: Pulmonary hypertension (PH), a rare complication in pregnant women, is assocaited with a high maternal mortality and poor pregnancy outcomes. The purpose of this study was to retrospectively analyze the outcomes of pregnancy complicated by PH for both. Methods and Results: The data of women with pregnancy complicated by PH who were admitted to our hospital between January 2015 and December 2018 were collected on their basic characteristics, clinical diagnoses, drug regimen, ultrasonographic diagnostic information, modes of delivery, and 1-year postpartum maternal and infant outcomes. The maternal and infant outcomes of women with different estimated pulmonary artery systolic pressure (PASP)levels were compared. The study included eighty-three pregnant women during the study period. Six subjects (7.2%) died during hospitalization and one subject (1.5% of the 68 subjects who were followed up) died within one year after delivery. A total of seventy-six infants (> 24 weeks old) were delivered by seventy-one subjects. There were fourty-six preterm infants (60.5%) and fourty-two low birth weight infants (55.3%). A significant increase in maternal mortality during hospitalization and low birth weight infants was observed in the group with an estimated PASP >70 mmHg (17.1% and 92.6%, respectively). Conclusion: Maternal mortality during pregnancy complicated by PH remained high, especially in women with an estimated PASP >70 mmHg. Multidisciplinary collaboration is required for the management of pregnancy in such patients to effectively improve maternal and infant outcomes.