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September 10, 2025Asian Pacific Journal of ReproductionOpen Access

Seminal exosomes and miRNA-mediated regulation of SRD5A2 in male infertility: An observational study

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Authors

AAAdnan F. AL-AzaawieMMMousa J. MohammedASAhmed AbdulJabbar Suleiman

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Overview

Observational study reveals crucial roles of seminal exosomes and miRNAs in male infertility, suggesting novel diagnostic biomarkers.

Key Points

  • Infertile men show lower seminal exosome levels compared to normozoospermics, highlighting a significant difference in exosome health.
  • SRD5A2 mRNA expression decreased in asthenozoospermia and oligozoospermia but increased in azoospermia, suggesting varied regulatory mechanisms.
  • Correlation analysis indicates that specific miRNAs negatively regulate SRD5A2 expression in some infertile groups, while revealing diverse interactions.
  • The study's findings support the potential of seminal exosome levels and miRNA expression as biomarkers for diagnosing male infertility.

Cite This Study

AL-Azaawie et al. (2025) studied this question.

synapsesocial.com/papers/68c1a40f54b1d3bfb60dec4bhttps://doi.org/10.4103/apjr.apjr_39_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of exosomal microRNAs miR-34a and miR-210 in male infertility: relationship with morphokinetic parameters and sperm DNA fragmentation2024 · 2 citations
  2. 2Predictive value of miR-122-5p, miR-449a, miR-30b-5p, miR-34c-5p, miR-34b-5p in sperm recovery from testicular tissue of azoospermic infertile men2026
  3. 3MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers2024 · 48 citations
  4. 4MicroRNA expression profiles in the seminal plasma of nonobstructive azoospermia patients with different histopathologic patterns2021 · 33 citations
  5. 5The Effects of miR‐425‐3p and Seminal Microbiota on Semen Parameters: Insights Into Male Infertility2025