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September 10, 2025European Heart Journal Supplements

Pathological spectrum of immune checkpoint myocarditis: The fast track ICI cohort study

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Authors

FCFrancesco CribariUniversity of Rome Tor VergataIHI. HamdiInstitute Mutualiste MontsourisSHSandra HenríquezInstitute Mutualiste Montsouris

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Overview

Prospective study correlates clinical features and histology in patients with ICI-myocarditis, suggesting complexity.

Key Points

  • ICI-myocarditis shows a spectrum, with some cases exhibiting significant T-cell infiltration without symptoms.
  • In 48 biopsies, 4 showed definite myocarditis, with a median of 114 T-cells/mm² in that group versus 16 T-cells/mm² in borderline cases.
  • Clinical correlations include higher CPK levels and more frequent hospitalization among patients with definite myocarditis patterns.
  • The findings indicate a need for established criteria for diagnosing ICI-myocarditis beyond the current Dallas criteria.

Cite This Study

Cribari et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5e554b1d3bfb60df280https://doi.org/10.1093/eurheartjsupp/suaf083.180
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune checkpoint inhibitor myocarditis: elucidating the spectrum of disease through endomyocardial biopsy2021 · 132 citations
  2. 2Clinicopathological classification of immune checkpoint inhibitor-associated myocarditis: possible refinement by measuring macrophage abundance2023 · 14 citations
  3. 3Immune checkpoint inhibitor associated myocarditis - lessons from a case series2025 · 1 citations
  4. 4Novel Insights into the Histopathological Characteristics of Immune Checkpoint Inhibitor-Related Myocarditis2026 · 1 citations
  5. 5Immune Checkpoint Inhibitor Myocarditis With Normal Cardiac Magnetic Resonance Imaging: Importance of Cardiac Biopsy and Early Diagnosis2020 · 14 citations