Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 26, 2020Canadian Journal of CardiologyOpen Access

Immune Checkpoint Inhibitor Myocarditis With Normal Cardiac Magnetic Resonance Imaging: Importance of Cardiac Biopsy and Early Diagnosis

View Full Paper
Ask AI
Bookmark
Share

Key result

Endomyocardial biopsy successfully diagnosed immune checkpoint inhibitor-related myocarditis in a patient who had normal cardiac magnetic resonance imaging.

Why the study?

Can endomyocardial biopsy diagnose ICI-related myocarditis in patients with a normal cardiac magnetic resonance imaging?

Population

1 patient treated with immune checkpoint inhibitors (ICIs) admitted for suspicion of myocarditis

Comparison

Endomyocardial biopsy (EMB) vs Cardiac magnetic resonance imaging (cMRI)

Design

Case_report

Authors

SÉStéphane ÉderhyCFCharlotte FeniouxCCClément Cholet

Discussion

Loading...

Member takes

Overview

EMB can identify ICI-myocarditis missed by cMRI; leaves open whether biopsy should supplement imaging in high-suspicion cases.

Study Design

Type

Case Report (n=1)

Structured PICO

Can endomyocardial biopsy diagnose ICI-related myocarditis in patients with a normal cardiac magnetic resonance imaging?

P
Population
A single patient treated with an immune checkpoint inhibitor who was admitted for suspected myocarditis.
I
Intervention
Endomyocardial biopsy (EMB)
C
Comparator
Cardiac magnetic resonance imaging (cMRI)
O
Outcome
Diagnosis of ICI-related myocarditis

Endomyocardial biopsy can diagnose ICI-related myocarditis even when cardiac MRI is normal, highlighting its potential value in suspected cases.

Cite This Study

Éderhy et al. (2020) conducted a case report in Immune checkpoint inhibitor-associated myocarditis (n=1). Endomyocardial biopsy (EMB) vs. Cardiac magnetic resonance imaging (cMRI) was evaluated on Diagnosis of ICI-related myocarditis. Endomyocardial biopsy successfully diagnosed immune checkpoint inhibitor-related myocarditis in a patient who had normal cardiac magnetic resonance imaging.

synapsesocial.com/papers/6ab3643e3550cfb2c045d018https://doi.org/10.1016/j.cjca.2020.12.022
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical and Advanced MRI Techniques for Detection of Checkpoint Inhibitor Associated Myocarditis2020 · 4 citations
  2. 2Role of Cardiac Imaging in the Diagnosis of Immune Checkpoints Inhibitors Related Myocarditis2021 · 18 citations
  3. 3Cardiac Magnetic Resonance Imaging in Immune Check-Point Inhibitor Myocarditis: A Systematic Review2022 · 20 citations
  4. 4Role of cardiac <scp>MRI</scp> in the diagnosis of immune checkpoint inhibitor‐associated myocarditis2022 · 33 citations
  5. 5Immune checkpoint inhibitor myocarditis: elucidating the spectrum of disease through endomyocardial biopsy2021 · 132 citations