Key result
Cardiac magnetic resonance imaging in ICI-myocarditis revealed mostly preserved LVEF, edema (9-60%), and LGE (23-83%), with native T1 mapping showing higher concordance with endomyocardial biopsy.
Why the study?
Several studies have investigated CMR in patients with ICI-myocarditis, but the available evidence on CMR findings had not been systematically summarized.
What are the characteristic cardiac magnetic resonance imaging findings and their prognostic value in patients with immune checkpoint inhibitor myocarditis?
Population
166 patients from five cohorts, plus 86 patients from a sub-analysis, with ICI-M across six studies
Design
Systematic review
Authors
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Preserved LVEF does not exclude ICI-myocarditis; extends CMR diagnostic criteria and supports native T1 validation.
Systematic Review (n=252)
What are the characteristic cardiac magnetic resonance imaging findings and their prognostic value in patients with immune checkpoint inhibitor myocarditis?
CMR in immune checkpoint inhibitor myocarditis demonstrates myocardial dysfunction, edema, and fibrosis, with native T1 mapping offering high concordance with biopsy and significant prognostic value.
Arcari et al. (2022) conducted a systematic review in Immune Check-Point Inhibitor Myocarditis (n=252). Cardiac magnetic resonance (CMR) imaging vs. Endomyocardial biopsy was evaluated on CMR findings including LVEF, edema, late gadolinium enhancement (LGE), and T1/T2 mapping. Cardiac magnetic resonance imaging in ICI-myocarditis revealed mostly preserved LVEF, edema (9-60%), and LGE (23-83%), with native T1 mapping showing higher concordance with endomyocardial biopsy.
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