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May 13, 2021Frontiers in OncologyOpen Access

Role of Cardiac Imaging in the Diagnosis of Immune Checkpoints Inhibitors Related Myocarditis

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Why the study?

Immune checkpoint inhibitor-related myocarditis has a high fatality rate and its diagnosis remains challenging, with limitations associated with cardiac magnetic resonance imaging.

Design

Review

Authors

SÉStéphane ÉderhyCardio-OncologyJoe‐Elie SalemJoe‐Elie SalemCross-Cutting CardiologyLDLaurent DercleMemorial Sloan Kettering Cancer Center

Discussion

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Implication

ICI myocarditis demands clinical vigilance given high fatality; review leaves open optimal prevention and management strategies.

Structured PICO

P
Population
Patients treated with immune checkpoint inhibitors (ICI) who develop or are at risk for cardiovascular toxicities, particularly myocarditis
I
Intervention
Medical imaging, including cardiac magnetic resonance imaging (cMRI), and endomyocardial biopsy
O
Outcome
Diagnosis, prognostication, and treatment decisions for ICI-related myocarditis

This review highlights the role and limitations of medical imaging, particularly cMRI, alongside endomyocardial biopsy in the diagnosis and management of ICI-related myocarditis.

Cite This Study

Éderhy et al. (2021) studied this question.

synapsesocial.com/papers/6a756ae91646b2abe503705chttps://doi.org/10.3389/fonc.2021.640985
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune Checkpoint Inhibitor Myocarditis With Normal Cardiac Magnetic Resonance Imaging: Importance of Cardiac Biopsy and Early Diagnosis2020 · 14 citations
  2. 2Cardiovascular toxicities associated with immune checkpoint inhibitors2019 · 521 citations
  3. 3Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper2009 · 2,527 citations
  4. 4MYOCARDITIS IN PATIENTS TREATED WITH IMMUNE CHECKPOINT INHIBITORS2018 · 113 citations
  5. 5Myocarditis in the Setting of Cancer Therapeutics2019 · 465 citations