Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 2020Current Cardiovascular Imaging ReportsOpen Access

Clinical and Advanced MRI Techniques for Detection of Checkpoint Inhibitor Associated Myocarditis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Immune checkpoint inhibitors can cause severe myocarditis, but established diagnostic guidelines are lacking and the gold standard endomyocardial biopsy is invasive with potential sampling errors.

Does cardiac magnetic resonance imaging accurately detect and characterize immune checkpoint inhibitor-associated myocarditis?

Design

Review

Authors

AAAmit ArbuneSouthwestern Medical CenterASAaron SouferYale UniversityLBLauren A. BaldassarreYale University

Discussion

Loading...

Member takes

Implication

CMR may aid ICI-myocarditis workup but evidence remains inconsistent; leaves open need for standardized protocols and prospective validation.

Structured PICO

Does cardiac magnetic resonance imaging accurately detect and characterize immune checkpoint inhibitor-associated myocarditis?

P
Population
Patients exposed to immune checkpoint inhibitors (ICIs) at risk for or with suspected myocarditis
I
Intervention
Cardiac magnetic resonance (CMR) imaging, including advanced parametric mapping techniques
O
Outcome
Diagnosis and tissue characterization of ICI-associated myocarditis

Cardiac magnetic resonance imaging is a vital noninvasive tool for diagnosing, prognosticating, and potentially screening for immune checkpoint inhibitor-associated myocarditis.

Cite This Study

Arbune et al. (2020) studied this question.

synapsesocial.com/papers/6a9240e2a592a3eaf2384049https://doi.org/10.1007/s12410-019-9521-5
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Use of Myocardial Strain Imaging by Echocardiography for the Early Detection of Cardiotoxicity in Patients During and After Cancer Chemotherapy2014 · 1,086 citations
  2. 2Managing cardiotoxicity associated with immune checkpoint inhibitors2019 · 84 citations
  3. 3Cardiac T1 Mapping and Extracellular Volume (ECV) in clinical practice: a comprehensive review2016 · 993 citations
  4. 4Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis2019 · 121 citations
  5. 5Relation between myocardial edema and myocardial mass during the acute and convalescent phase of myocarditis – a CMR study2008 · 87 citations