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September 10, 2025International Journal of Research in Pharmaceutical SciencesOpen Access

Long-term exposure to sildenafil-adulterated herbal aphrodisiacs induces oxidative and functional alterations in the prostate and seminal vesicles of male rats

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Authors

NONoufou OuedraogoBTBasile TindanoDMDoukoure Maya

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Overview

Observational analysis reveals oxidative stress and functional disruptions in prostate and seminal vesicles, indicating the risks of herbal aphrodisiac use.

Key Points

  • Chronic exposure to sildenafil-adulterated herbal aphrodisiacs disrupts reproductive health in male rats, inducing oxidative stress.
  • Biochemical analyses showed significant reductions in seminal vesicle fructose and prostatic enzyme activities, indicating dysfunction.
  • Histopathological examinations revealed glandular degeneration and epithelial hyperplasia, particularly at higher doses of sildenafil.
  • These findings underscore the need for stricter regulations on herbal products containing synthetic drugs to protect public health.

Cite This Study

Ouedraogo et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5eb54b1d3bfb60df3fbhttps://doi.org/10.26452/ijrps.v16i3.4787
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Testicular toxicity induced by chronic exposure to two adulterated traditional aphrodisiacs named Attoté and Congnons-moussos containing sildenafil in Wistar rats2026
  2. 2Sildenafil Citrate Induces Prostatic Hyperplasia in BPH Model Rats and Aged Rats2024
  3. 3Effect of Sildenafil Citrate on Some Reproductive and Other Physiologic Parameters of Albino Rats (Rattus norvegicus)2025
  4. 4Effects of phosphodiesterase 5 inhibitor (viagra) on biochemical parameters of l-name-induced testicular toxicity in adult male wistar rats2024 · 1 citations
  5. 5In vivo efficacy of new polyherbal combination in sexual behavior male rat model2026