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September 10, 2025Journal of Veterinary and Biomedical Sciences

Effect of Sildenafil Citrate on Some Reproductive and Other Physiologic Parameters of Albino Rats (Rattus norvegicus)

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Authors

OAOluwa Adikpe AgbonuCOChianumba Franklin Onyi

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Overview

Investigation indicates sildenafil citrate alters physiological parameters in albino rats, implying potential risks.

Key Points

  • Sildenafil citrate increases serum testosterone and sexual activity in albino rats, enhancing reproductive functions.
  • Sub-acute exposure to sildenafil citrate causes significant declines in sperm count and motility, indicating adverse effects.
  • Haematological analyses reveal alterations in blood parameters, while liver function tests confirm hepatotoxic effects at higher doses.
  • Regulated use of sildenafil citrate is essential to mitigate risks associated with chronic exposure and non-prescribed usage.

Cite This Study

Agbonu et al. (2025) studied this question.

synapsesocial.com/papers/68c1a8fe54b1d3bfb60e1ab6https://doi.org/10.36108/jvbs/5202.70.0110
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of combination of tramadol and sildenafil citrate (Viagra) on hepatic and renal function parameters in Male Albino Rats2024 · 1 citations
  2. 2Long-term exposure to sildenafil-adulterated herbal aphrodisiacs induces oxidative and functional alterations in the prostate and seminal vesicles of male rats2025
  3. 3Sildenafil Citrate Induces Prostatic Hyperplasia in BPH Model Rats and Aged Rats2024
  4. 4Effects of phosphodiesterase 5 inhibitor (viagra) on biochemical parameters of l-name-induced testicular toxicity in adult male wistar rats2024 · 1 citations
  5. 5Testicular toxicity induced by chronic exposure to two adulterated traditional aphrodisiacs named Attoté and Congnons-moussos containing sildenafil in Wistar rats2026