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May 16, 2026Clinical Traditional Medicine and PharmacologyOpen Access

Testicular toxicity induced by chronic exposure to two adulterated traditional aphrodisiacs named Attoté and Congnons-moussos containing sildenafil in Wistar rats

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Authors

NONoufou OuedraogoBTBasile TINDANOASAbdoul Karim Sakira

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Overview

Randomized trial evaluates testicular toxicity in Wistar rats exposed to sildenafil-adulterated aphrodisiacs, indicating health risks.

Key Points

  • This study evaluates the testicular toxicity induced by chronic exposure to sildenafil-adulterated traditional aphrodisiacs in male Wistar rats.
  • Male Wistar rats were administered distilled water (control) or sildenafil and two formulations of adulterated aphrodisiacs for 90 days.
  • Doses of sildenafil and aphrodisiacs ranged from 5 mg/kg bw to 200 mg/kg bw.
  • Testicular toxicity was assessed through hormonal measurements, biochemical parameters, oxidative stress biomarkers, and histopathology.
  • Chronic exposure to the adulterated formulations caused a dose-dependent reduction in relative testicular weight and serum testosterone levels, especially with high doses of CM.
  • Elevated concentrations of FSH and LH were observed at higher doses, indicating endocrine disruption.
  • Histopathological examinations revealed severe degenerative alterations in seminiferous tubules with high-dose treatments.

Cite This Study

Ouedraogo et al. (2026) studied this question.

synapsesocial.com/papers/6a080ae2a487c87a6a40cf00https://doi.org/10.1016/j.ctmp.2026.200282
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  5. 5Effect of Sildenafil Citrate on Some Reproductive and Other Physiologic Parameters of Albino Rats (Rattus norvegicus)2025