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September 10, 2025Advanced Functional Materials

NIR Light‐Controlled Cascade Regulation of Mixed‐Valence Copper (I)/(II) Nanozyme (Cu2−xSe) Spray for Infectious Wound Healing

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Authors

BPBin PanYJYang JinYCYan Chen

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Overview

This innovative spray enhances antibacterial effects using mixed-valence copper ions, suggesting improved wound healing outcomes.

Key Points

  • The Cu2−xSe nanozyme spray eliminates over 99% of MRSA under NIR light exposure, demonstrating strong antibacterial properties.
  • In vitro and in vivo studies illustrate that the spray also promotes tissue regeneration by binding to KEAP1, inhibiting inflammation.
  • The method employs chemodynamic therapy (CDT) by releasing copper ions that work effectively against infectious wounds.
  • This dual-action strategy addresses antibiotic resistance while supporting tissue healing in complex wound scenarios.

Cite This Study

Pan et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5eb54b1d3bfb60df515https://doi.org/10.1002/adfm.202507799
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Also Consider

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  1. 1Dynamic Antibacterial‐to‐Regenerative Switching via NIR/Visible Light Activation: Copper Single‐Atom Nanozyme with CO‐Mediated Scarless Healing for Chronic Diabetic Wounds2025 · 8 citations
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  3. 3NIR light-activated nanocomposites combat biofilm formation and enhance antibacterial efficacy for improved wound healing2024 · 7 citations
  4. 4Sequential Regulation of Local Reactive Oxygen Species by Ir@Cu/Zn-MOF Nanoparticles for Promoting Infected Wound Healing2024 · 6 citations
  5. 5Bacteria-Targeted Single-Atom Nanozyme With Photothermal-Augmented Multi-Enzymatic Cascade and NO Delivery for Enhanced Infected Wound Healing.2025 · 15 citations