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September 10, 2025Frontiers in ImmunologyOpen Access

Study of dense granule proteins in Eimeria spp. identifies a limited repertoire with potential as vaccine candidates

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Authors

GSGonzalo Sanchez-ArsuagaDBDamer P. BlakeFTFiona M. Tomley

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Overview

Observational analysis suggests potential vaccine candidates in Eimeria spp., indicating scalable approaches to combat coccidiosis.

Key Points

  • Immunisation with recombinant EtGRA9 reduced parasite load in chickens by 85.7%, indicating its vaccine potential.
  • A limited number of dense granule proteins were identified in Eimeria spp., compared to Toxoplasma gondii.
  • Eimeria tenella showed a reduced GRA protein repertoire, suggesting selective pressure on these proteins.
  • The study highlights a new avenue for developing effective vaccines against coccidiosis, specifically in poultry.

Cite This Study

Sanchez-Arsuaga et al. (2025) studied this question.

synapsesocial.com/papers/68c1a77254b1d3bfb60e08b1https://doi.org/10.3389/fimmu.2025.1605984
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of highly cross-reactive immunogens in2025
  2. 2Conserved proteins of Eimeria and their applications to develop universal subunit vaccine against chicken coccidiosis2024 · 2 citations
  3. 3Eimeria tenella apical membrane 2 overexpression enhances pathogenicity and immunity in chickens2025
  4. 4Protective efficacy of Eimeria maxima EmLPL and EmTregIM-1 against homologous challenge in chickens2024 · 2 citations
  5. 5The spatial proteome of Eimeria tenella provides a high-resolution view of proteins localised to key invasion organelles2026 · 1 citations