Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 6, 2025Parasites & VectorsOpen Access

Eimeria tenella apical membrane 2 overexpression enhances pathogenicity and immunity in chickens

View Full Paper
Ask AI
Bookmark
Share

Authors

SWShanbo WuShanghai Veterinary Research InstituteLWLihui WangGenedata (Switzerland)JWJinwen WangNorth University of China

Discussion

Loading...

Member takes

Overview

Experimental analysis demonstrates increased pathogenicity and immunogenicity in chickens, suggesting Et AMA2 as a vaccine target for coccidiosis.

Key Points

  • Significant increase in pathogenicity was observed with Et AMA2-OE, leading to severe cecal lesions and heightened oocyst output.
  • Immunized chicks showed notably improved immunity, reducing oocyst shedding and cecal lesions post-infection.
  • Transcriptional profiling using RT-qPCR identified Et AMA2's role in pathogenesis, affirming its potential as a virulence factor.
  • Overall findings indicate dual functions of Et AMA2 in pathogenicity and as a promising vaccine antigen, supporting future coccidiosis vaccine development.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/694020fd2d562116f28fb5f3https://doi.org/10.1186/s13071-025-07185-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional characterization of EtAMA3 in Eimeria tenella and immunogenicity of its knockout line2026
  2. 2<i>Eimeria tenella</i> AMA1 regulates host cell apoptosis through the mitochondrial pathway and the death receptor pathway2025
  3. 3Study of dense granule proteins in Eimeria spp. identifies a limited repertoire with potential as vaccine candidates2025
  4. 4Identification of highly cross-reactive immunogens in2025
  5. 5Expression of IL-1β in transgenic Eimeria necatrix enhances the immunogenicity of parasites and promotes mucosal immunity against coccidiosis2024 · 9 citations