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December 6, 2025Parasites & VectorsOpen Access

Eimeria tenella apical membrane 2 overexpression enhances pathogenicity and immunity in chickens

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Authors

SWShanbo WuLWLihui WangJWJinwen Wang

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Overview

Experimental analysis demonstrates increased pathogenicity and immunogenicity in chickens, suggesting Et AMA2 as a vaccine target for coccidiosis.

Key Points

  • Significant increase in pathogenicity was observed with Et AMA2-OE, leading to severe cecal lesions and heightened oocyst output.
  • Immunized chicks showed notably improved immunity, reducing oocyst shedding and cecal lesions post-infection.
  • Transcriptional profiling using RT-qPCR identified Et AMA2's role in pathogenesis, affirming its potential as a virulence factor.
  • Overall findings indicate dual functions of Et AMA2 in pathogenicity and as a promising vaccine antigen, supporting future coccidiosis vaccine development.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/694020fd2d562116f28fb5f3https://doi.org/10.1186/s13071-025-07185-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional characterization of EtAMA3 in Eimeria tenella and immunogenicity of its knockout line2026
  2. 2<i>Eimeria tenella</i> AMA1 regulates host cell apoptosis through the mitochondrial pathway and the death receptor pathway2025
  3. 3Study of dense granule proteins in Eimeria spp. identifies a limited repertoire with potential as vaccine candidates2025
  4. 4Identification of highly cross-reactive immunogens in2025
  5. 5Expression of IL-1β in transgenic Eimeria necatrix enhances the immunogenicity of parasites and promotes mucosal immunity against coccidiosis2024 · 9 citations