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August 25, 2025Microbiology SpectrumOpen Access

Eimeria tenella AMA1 regulates host cell apoptosis through the mitochondrial pathway and the death receptor pathway

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Authors

XLXiaoling LüLWLiwen WangSDSichen Dong

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Overview

Experimental analysis reveals et ama1 inhibits apoptosis in host cells, suggesting potential for coccidiostats and vaccines.

Key Points

  • Et ama1 inhibition of apoptosis was confirmed through both mitochondrial and death receptor pathways.
  • Key findings indicated successful expression of et ama1 and its role in inhibiting host cell apoptosis.
  • Assessment utilized techniques like western blot, fluorescence staining, and transmission electron microscopy.
  • These insights may enable the development of new strategies for coccidiostats and vaccines against eimeria tenella.

Cite This Study

Lü et al. (2025) studied this question.

synapsesocial.com/papers/68af5d69ad7bf08b1eae0affhttps://doi.org/10.1128/spectrum.00416-25
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Also Consider

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  1. 1Eimeria tenella apical membrane 2 overexpression enhances pathogenicity and immunity in chickens2025
  2. 2Mechanistic Insights into Eimeria tenella-Induced Host Cell Apoptosis Through Modulation of the Mitochondrial Permeability Transition Pore2025
  3. 3Influence of Different Death Receptor Signaling Pathways on Apoptosis of Eimeria tenella Host Cells2026
  4. 4PATHOGENIC MECHANISM OF EIMERIA TENELLA EtMIC2 promotes Eimeria tenella invasion and inhibits host cell apoptosis through binding to the ITGAV receptor2026 · 1 citations
  5. 5EtROP38 suppresses apoptosis of host cells infected with Eimeria tenella by inhibition of the p38MAPK pathway2024 · 2 citations