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September 16, 2025MicroorganismsOpen Access

Mechanistic Insights into Eimeria tenella-Induced Host Cell Apoptosis Through Modulation of the Mitochondrial Permeability Transition Pore

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Authors

RBRui BaiSZShuying ZhuHWHui Wang

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Overview

Observation reveals Eimeria tenella triggers apoptosis in host cells, suggesting MPTP as a therapeutic target.

Key Points

  • Eimeria tenella infection significantly increases pro-apoptotic factors in host cells, promoting apoptosis.
  • Inhibition of the mitochondrial permeability transition pore reduces apoptosis markers, suggesting a protective effect.
  • The study utilized a chicken embryo model to assess the impact of MPTP on apoptotic signaling during infection.
  • This research highlights the potential of targeting MPTP in mitigating Eimeria tenella-induced host cell damage.

Cite This Study

Bai et al. (2025) studied this question.

synapsesocial.com/papers/68d454d131b076d99fa5a796https://doi.org/10.3390/microorganisms13092139
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1EtROP38 suppresses apoptosis of host cells infected with Eimeria tenella by inhibition of the p38MAPK pathway2024 · 2 citations
  2. 2Influence of Different Death Receptor Signaling Pathways on Apoptosis of Eimeria tenella Host Cells2026
  3. 3An Integrated Model of Biphasic Apoptosis in Avian Coccidiosis: Molecular Networks and Host–Parasite Interplay2025
  4. 4<i>Eimeria tenella</i> AMA1 regulates host cell apoptosis through the mitochondrial pathway and the death receptor pathway2025
  5. 5Intestinimonas butyriciproducens affects Eimeria tenella development and infection via regulating EtGFAT gene expression2024