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May 8, 2026International Journal for ParasitologyOpen Access

The spatial proteome of Eimeria tenella provides a high-resolution view of proteins localised to key invasion organelles

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Authors

EAE. AttreeKBK. BarylyukCNC. Noonan

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Overview

Randomized trial uncovers protein localizations in Eimeria tenella, suggesting mechanisms of virulence.

Key Points

  • This research aims to map the spatial distribution of proteins in Eimeria tenella, particularly those involved in invasion.
  • Utilized hyperLOPIT for high-throughput spatial proteomics
  • Applied Bayesian machine learning for localization assignments
  • Identified 722 proteins with localization to 12 subcellular niches
  • Assigned 49 proteins to micronemes and 70 proteins to rhoptries with high confidence
  • Observations suggest functional divergence in surface antigen A and B proteins
  • Identified a conserved ortholog of SPATR in micronemes, indicating its role in host cell invasion

Cite This Study

Attree et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e90bfa21ec5bbf06d27https://doi.org/10.1016/j.ijpara.2026.104878
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Also Consider

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  1. 1Comprehensive Lysine Ubiquitome Profiling Reveals Diverse Functions of Lysine Ubiquitination in <i>Eimeria tenella</i>.2026
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