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May 1, 2026Veterinary ResearchOpen Access

Integrative comparative genomics and transcriptomics reveal key roles of SAG17 and SAG23 in early-stage virulence divergence of Eimeria tenella

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Authors

YHYe HeGuizhou UniversityXWXiang WanLonggang Central HospitalXWXuan WangGuizhou Academy of Agricultural Sciences

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Implication

Integrative genomic and transcriptomic analyses demonstrate SAG17 and SAG23's role in virulence divergence in Eimeria tenella strains, indicating potential vaccine targets.

Key Points

  • This research aims to understand the molecular mechanisms behind the virulence divergence of Eimeria tenella strains.
  • Integrated clinical phenotypes, histopathology, cytokine assays, whole-genome resequencing, and transcriptome analyses.
  • Compared the Beijing and Guizhou strains of Eimeria tenella.
  • Conducted functional validation of recombinant SAG17 and SAG23 proteins.
  • Guizhou strain caused more severe symptoms and intestinal lesions in chickens.
  • Significant genomic variations in surface antigen genes were found in the Guizhou strain.
  • Recombinant SAG17 and SAG23 proteins inhibited sporozoite invasion and enhanced IFN-γ and IgG levels.

Cite This Study

He et al. (2026) studied this question.

synapsesocial.com/papers/69f44325967e944ac55668b6https://doi.org/10.1186/s13567-026-01730-0
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