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September 10, 2025Journal of Tissue EngineeringOpen Access

From niche to organoid: Engineering bone tissues through microenvironmental insights

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Authors

XYXu YanLSLingchao ShengMZMin Zhu

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Overview

Review reveals crucial role of skeletal microenvironment and extracellular matrix in organoid development, suggesting transformative effects in tissue engineering.

Key Points

  • Bone organoids offer new opportunities for studying bone biology and regenerative medicine, revolutionizing tissue engineering.
  • Key factors like extracellular matrix and mechanical cues critically influence the construction of viable bone organoids.
  • Insights into microenvironmental elements support advancements in biomaterials, enhancing organoid development for drug screening.
  • Microenvironment-driven strategies may significantly impact personalized medicine and bone regeneration in clinical settings.

Cite This Study

Yan et al. (2025) studied this question.

synapsesocial.com/papers/68c1aacc54b1d3bfb60e36eehttps://doi.org/10.1177/20417314251358567
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Emerging engineering strategies in bone organoids: From biomimetic scaffolds to dynamic microenvironmental stimulation2026
  2. 2Applications of Bone Organoids in Bone Regeneration: Unveiling New Strategies for Disease Mechanisms and Drug Screening2026
  3. 3Engineering bone organoids: Recent advances and future prospects2025
  4. 4Advances in Bone Organoids Research and Future Perspectives2025 · 2 citations
  5. 5Bone Organoids as Advanced Models for Osteoporosis: Development, Application, and Future Prospects2026 · 2 citations