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April 19, 2026Bioactive MaterialsOpen Access

Emerging engineering strategies in bone organoids: From biomimetic scaffolds to dynamic microenvironmental stimulation

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Authors

JHJiamian HanHGHongcheng GuZGZhongze Gu

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Overview

This review explores engineering strategies to enhance bone organoids for disease modeling and personalized medicine.

Key Points

  • To review advanced engineering strategies that address the challenges in creating functional bone organoids.
  • Critically examine biomimetic scaffolds and dynamic mechanical microenvironments.
  • Assess the integration of 3D bioprinting and microfluidic organ-on-a-chip systems.
  • Discuss the role of artificial intelligence in bone organoid development.
  • Engineering strategies are essential for constructing structural bone organoids.
  • Biomimetic scaffolds can guide cell fate effectively.
  • Stimuli-responsive materials enable enhanced mechanical environments for bone organoids.
  • Integrated platforms facilitate better vascularization and improve disease modeling.

Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/69e473bd010ef96374d8f8b1https://doi.org/10.1016/j.bioactmat.2026.04.008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Engineering bone organoids: Recent advances and future prospects2025
  2. 2Applications of Bone Organoids in Bone Regeneration: Unveiling New Strategies for Disease Mechanisms and Drug Screening2026
  3. 3From niche to organoid: Engineering bone tissues through microenvironmental insights2025 · 11 citations
  4. 4Advances in Bone Organoids Research and Future Perspectives2025 · 2 citations
  5. 5Bone Organoids as Advanced Models for Osteoporosis: Development, Application, and Future Prospects2026 · 2 citations