Photochemical trifluoromethylation produces fused indoles without photocatalysts, indicating a novel mechanism.
A photochemical trifluoromethylation/cyclization of alkenes to access trifluoromethyl‐substituted fused indoles using trifluoromethylsulfonyl‐pyridinium salt (TFSP) is achieved under photocatalyst‐free conditions. Mechanistic studies revealed the formation of an electron donor–acceptor complex between indole and TFSP, distinguishing this protocol from iridium‐catalyzed TFSP‐based trifluoromethylation reactions and suggesting a different mechanistic pathway.
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Sun et al. (2025) studied this question.
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