A colorimetric and turn-on fluorescent probe for visualization of lysosomal pH fluctuation

Xiaofei Yin; Boyang Zhang; Y. N. Wang; Ning Du; Zongxing Wang; Jianbu Wang; Qihua You

doi:10.1039/d5ay00791g

January 1, 2025Analytical Methods

A colorimetric and turn-on fluorescent probe for visualization of lysosomal pH fluctuation

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Key Points

The probe effectively detects lysosomal pH changes in living cells, enhancing observation capabilities.
With a p K a value of 6.73, the probe shows sensitivity in acidic environments typically found in lysosomes.
The method employs a colorimetric and turn-on strategy, suitable for real-time monitoring of cellular conditions.
Utilizing chloroquine and heat stroke as stimulants, this technology can improve our understanding of cell physiology.

Implication

Fluorescent probe visualizes lysosomal pH changes under chloroquine and heat stroke, implying potential cellular applications.

Abstract

A turn-on pH fluorescent probe with a suitable p K a value of 6.73 has been designed and investigated. The probe can be applied to visualize lysosomal pH changes in living cells under stimulation by chloroquine and heat stroke, respectively.

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Cite This Study

Yin et al. (2025) studied this question.

synapsesocial.com/papers/68c1ad5c54b1d3bfb60e56e2 https://doi.org/10.1039/d5ay00791g

View Full Paper

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A colorimetric and turn-on fluorescent probe for visualization of lysosomal pH fluctuation

Key Points

Implication

Abstract

Discussion

Cite This Study

A colorimetric and turn-on fluorescent probe for visualization of lysosomal pH fluctuation

Key Points

Implication

Abstract

Discussion

Cite This Study

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