In vitro study demonstrates targeted near-infrared lysosomal tracking in HeLa cells, indicating utility as an organelle-specific biosensor.
A cyanobenzo[a]phenoxazine-based pH probe with pKa = 5.0 exhibits OFF-ON emission at 625-850 nm upon excitation at 600 nm in aqueous buffers. The in cellulo imaging experiments with HeLa cells indicate that the probe can serve as a lysosome-specific probe under red light excitation (633 nm) with near infrared emission (650-790 nm).
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Sun et al. (2013) studied this question.
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