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Comparative Evaluation of Intrathecal Clonidine and Nalbuphine as an Adjuvant to Hyperbaric Ropivacaine in Subarachnoid Block

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Randomized trial compares onset and duration of anesthesia in lower limb surgeries, suggesting clonidine may enhance outcomes.

Clonidine and nalbuphine both significantly reduce onset times of sensory block compared to ropivacaine alone.
Sensory block duration is prolonged with clonidine and nalbuphine, showing significant improvements over control.
Motor block durations favor clonidine over nalbuphine and ropivacaine alone, indicating enhanced anesthesia performance.
Increased hypotension incidence is observed with clonidine use, highlighting a risk associated with improved block characteristics.

Sehgal et al. (2025) studied this question.

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