Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025ACS Polymers AuOpen Access

Enhanced Antifungal Efficacy through Controlled Delivery of Amphotericin B Loaded in Polyetheramine-Epoxide Nanogels

View Full Paper
Ask AI
Bookmark
Share

Authors

JRJulia S. ReinaldiHAHeber E. AndradaASArmando Silva‐Cunha

Discussion

Loading...

Member takes

Overview

Controlled release of amphotericin b in nanogel carriers improves antifungal efficacy, indicating better therapeutic outcomes.

Key Points

  • Controlled release of encapsulated amphotericin b led to a 4-fold enhancement in antifungal activity.
  • Nanogel system achieved approximately 55% amphotericin b loading capacity, maximizing its therapeutic potential.
  • Synthesis of polymeric nanogels involved amine-epoxide reactions, ensuring eco-friendly engineering and effective encapsulation.
  • Mechanistic studies suggest sustained release and electrostatic interactions contribute to the antifungal efficacy of the nanogels.

Cite This Study

Reinaldi et al. (2025) studied this question.

synapsesocial.com/papers/68c1afc054b1d3bfb60e7479https://doi.org/10.1021/acspolymersau.5c00037
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Beyond the Charge: Interplay of Nanogels’ Functional Group and Zeta‐Potential for Antifungal Drug Delivery to Human Pathogenic Fungus <i>Aspergillus fumigatus</i>2024 · 2 citations
  2. 2Nanogel Formulation for Enhanced Fungal Infection Treatment2025
  3. 3Development ofOral pH-Sensitive Eudragit L100-Functionalized <i>Bombyx mori</i> Silk Fibroin Nanoparticles ContainingAmphotericin B: Formulations, Characterizations, <i>In Silico</i> Molecular Investigations, and Antifungal Activity Evaluation2026
  4. 4FORMULATION AND EVALUATION OF AMPHOTERICIN B-LOADED CUBOSOMES: A COMPREHENSIVE REVIEW2026
  5. 5Unleashing Fungicidal Forces: Exploring the Synergistic Power of Amphotericin B-Loaded Nanoparticles and Monoclonal Antibodies2024 · 4 citations