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August 13, 2026ACS OmegaOpen Access

Development ofOral pH-Sensitive Eudragit L100-Functionalized Bombyx mori Silk Fibroin Nanoparticles ContainingAmphotericin B: Formulations, Characterizations, In Silico Molecular Investigations, and Antifungal Activity Evaluation

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Authors

BTBùi Thị Phương ThuýVan Lang UniversityPHPhuong T. M. HaCan Tho UniversityNNNgoc Yen NguyenCan Tho University

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Overview

Randomized trial evaluates antifungal activity of Eudragit L100-functionalized nanoparticles containing Amphotericin B, suggesting improved oral delivery.

Key Points

  • The aim is to enhance oral bioavailability and reduce nephrotoxicity of Amphotericin B using silk fibroin nanoparticles.
  • Developed Eudragit L100-functionalized silk fibroin nanoparticles using desolvation and adsorption methods
  • Characterized particle size, zeta potential, drug loading efficiency, and drug release under simulated oral conditions
  • Conducted in vitro antifungal activity assessments against Candida albicans with IC50 and MIC determinations.
  • Optimal formulation had particles of average size 577.9 nm and zeta potential -47.9 mV
  • Produced 77.99% drug loading efficiency, with moderate antifungal activity (IC50: 4.09 μg/mL, MIC: 32.0 μg/mL)
  • Demonstrated protection of Amphotericin B in acidic conditions and controlled drug release in the small intestine.

Cite This Study

Thuý et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76aa2b0e0cff3f640359https://doi.org/10.1021/acsomega.6c01865
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Eudragit E100/silk fibroin hybrid nanoparticles for the controlled oral delivery of amphotericin B.2026 · 3 citations
  2. 2Enhanced Antifungal Efficacy through Controlled Delivery of Amphotericin B Loaded in Polyetheramine-Epoxide Nanogels2025 · 4 citations
  3. 3Enhanced Dissolution of Amphotericin B through Development of Amorphous Solid Dispersions Containing Polymer and Surfactants2024 · 3 citations
  4. 4Preparation and in vitro evaluation of amphotericin B-chondroitin sulfate polymer prodrug2026
  5. 5Development of pH-responsive Eudragit S100-functionalized silk fibroin nanoparticles as a prospective drug delivery system2024 · 24 citations