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June 9, 2026PolymersOpen Access

Potentiated Activity of Amphotericin B-Loaded PLGA Nanoparticles Against Aspergillus fumigatus

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Authors

AOAnastasia OrekhovaLomonosov Moscow State UniversityASAndrey V. SybachinLomonosov Moscow State UniversityVLVeronika LyaminaLomonosov Moscow State University

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Implication

Randomized trial demonstrates improved antifungal activity in Galleria mellonella models, suggesting a novel treatment option.

Key Points

  • The study aims to evaluate the efficacy and safety of amphotericin B-loaded PLGA nanoparticles in treating A. fumigatus infections.
  • Characterization of PLGA-AmB-NPs for physicochemical properties and antifungal activity.
  • In vivo testing in Galleria mellonella infection model to assess survival rates.
  • In vitro analysis of hemolytic toxicity across various concentrations.
  • PLGA-AmB-NPs demonstrated enhanced antifungal activity against A. fumigatus biofilms at 5 and 10 µg/mL compared to free AmB.
  • Survival of G. mellonella larvae treated with PLGA-AmB-NPs was significantly improved over 5 days.
  • PLGA-AmB-NPs exhibited substantially lower hemolysis of human red blood cells across all tested concentrations (5–20 µg/mL).

Cite This Study

Orekhova et al. (2026) studied this question.

synapsesocial.com/papers/6a27adf8a963992e162680e8https://doi.org/10.3390/polym18121421
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