May 10, 2024Journal of FungiOpen Access

Unleashing Fungicidal Forces: Exploring the Synergistic Power of Amphotericin B-Loaded Nanoparticles and Monoclonal Antibodies

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Authors

CSCarla Soares de Souza VLVictor Ropke da Cruz Lopes GBGabriel Barcellos

Discussion

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Overview

In vitro study demonstrates synergistic fungicidal activity in pathogenic fungal cultures, suggesting an effective strategy to overcome antifungal resistance.

Key Points

Combining amphotericin b nanoparticles with monoclonal antibodies markedly intensifies antifungal activity, producing a synergistic effect against resistant pathogenic fungi.
Antifungal activity increased two to four times over amphotericin b nanoparticles alone, while minimum inhibitory concentrations dropped as low as 0.031 µg/mL in fungal assays.
Nanoprecipitation using polycaprolactone produced non-toxic nanoparticles that may enable safer fungal therapy, though findings remain limited to in vitro and cell culture models.

Cite This Study

Souza et al. (2024) studied this question.

synapsesocial.com/papers/68e6ab16b6db64358762d22f https://doi.org/10.3390/jof10050344

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May 10, 2024Journal of FungiOpen Access

Unleashing Fungicidal Forces: Exploring the Synergistic Power of Amphotericin B-Loaded Nanoparticles and Monoclonal Antibodies

View Full Paper

Ask AI

Bookmark

Authors

CSCarla Soares de Souza VLVictor Ropke da Cruz Lopes GBGabriel Barcellos

Discussion

Member takes

Overview

In vitro study demonstrates synergistic fungicidal activity in pathogenic fungal cultures, suggesting an effective strategy to overcome antifungal resistance.

Key Points

Combining amphotericin b nanoparticles with monoclonal antibodies markedly intensifies antifungal activity, producing a synergistic effect against resistant pathogenic fungi.
Antifungal activity increased two to four times over amphotericin b nanoparticles alone, while minimum inhibitory concentrations dropped as low as 0.031 µg/mL in fungal assays.
Nanoprecipitation using polycaprolactone produced non-toxic nanoparticles that may enable safer fungal therapy, though findings remain limited to in vitro and cell culture models.

Cite This Study

Souza et al. (2024) studied this question.

synapsesocial.com/papers/68e6ab16b6db64358762d22f https://doi.org/10.3390/jof10050344

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