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September 10, 2025Bulletin of the National Research Centre/Bulletin of the National Research CenterOpen Access

Salivary chromogranin a reflects autonomic regulation during “wake to sleep” and “sleep to wake” transitions

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Authors

KTK TaniguchiASAkitoshi Seiyama

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Overview

This observational analysis reveals associations between salivary chromogranin A and parasympathetic nervous activity during sleep-wake transitions, indicating their interlinked role.

Key Points

  • Salivary CgA levels after waking reflect changes in parasympathetic nervous activity during sleep-wake transitions.
  • A smaller decrease in heart rate variability from sleep to waking correlated with lower CgA levels after waking (p = 0.024).
  • Using saliva samples, the study measured heart rate variability as an index for parasympathetic nervous activity related to sleep-wake transitions.
  • Findings support the use of salivary CgA and heart rate variability as indicators of sleep quality and autonomic regulation.

Cite This Study

Taniguchi et al. (2025) studied this question.

synapsesocial.com/papers/68c1b18554b1d3bfb60e866ahttps://doi.org/10.1186/s42269-025-01340-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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  4. 4Comparison of Salivary Stress Biomarkers in Patients with and without Periodontal Diseases: A Cross-sectional Study.2026
  5. 5The association of salivary alpha-amylase, heart rate variability, and psychological stress on objectively measured sleep behaviors among college students2022 · 3 citations